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Current research in my laboratory focuses on adaptor protein trafficking within the endolysosomal system, autophagy, and macropinocytosis. These pathways are essential for cellular homeostasis, as they coordinate cargo recognition, vesicle transport, and degradation. Our goal is to define the molecular mechanisms by which adaptor proteins regulate cargo sorting, vesicle tethering, and fusion events across these trafficking routes. We employ biochemical and biophysical approaches to elucidate the structural and functional basis of adaptor protein interactions, identify regulatory binding interfaces, and characterize membrane insertion processes at molecular to atomic resolution. These studies provide mechanistic insight into how adaptor proteins integrate lipid signals with protein trafficking and how their dysregulation contributes to human disease.

Keywords:
Protein - lipids – membrane insertion – protein structure – membrane trafficking