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Integrated Cellular Responses Laboratory | The Finkielstein Lab Logo with white text

Protein Signaling Domains Laboratory | Capelutto Research Group Logo with white text

     

     

Welcome from the Director...

Our current research centers on the molecular structure and biochemical functions of signaling transduction systems involved in membrane trafficking and cell signaling. Our goal is to understand how protein domains transduce cell signaling from biological membranes. Our laboratory employs biophysical approaches including high field nuclear magnetic resonance spectroscopy, circular dichroism, computer modeling, fluorescence spectroscopy, and surface plasmon resonance spectroscopy to determine ligand binding pockets and membrane insertion of protein domains from molecular to atomic resolution. We validate our functional and structural approaches by using normal and disease-associated cell lines. With these tools we can establish how protein-ligand interactions control the function of proteins by modulating their subcellular localization.

Keywords:
Protein domains- lipids – membrane insertion – protein structure – membrane trafficking – subcellular localization of proteins

     

Featured Publications... 

PNAS November 22, 2016 113 (47) 13516-13521; first published November 9, 2016 https://doi.org/10.1073/pnas.1607984113

PNAS November 22, 2016 113 (47) 13516-13521; first published November 9, 2016 https://doi.org/10.1073/pnas.1607984113

Selfridge, J.M., Gotoh, T., Schiffhauer, S. et al. Chronotherapy: Intuitive, Sound, Founded…But Not Broadly Applied. Drugs 76, 1507–1521 (2016).

Selfridge, J.M., Gotoh, T., Schiffhauer, S. et al. Chronotherapy: Intuitive, Sound, Founded…But Not Broadly Applied. Drugs 76, 1507–1521 (2016).