Our current research centers on the molecular structure and biochemical functions of signaling transduction systems involved in membrane trafficking and cell signaling. Our goal is to understand how protein domains transduce cell signalling from biological membranes. Our laboratory employs biophysical approaches including high field nuclear magnetic resonance spectroscopy, circular dichroism, computer modeling, fluorescence spectroscopy, and surface plasmon resonance spectroscopy. to determine ligand binding pockets and membrane insertion of protein domains from molecular to atomic resolution. We validate our functional and structural approaches by using normal and disease-associated cell lines. With these tools, we can establish how protein-ligand interactions control the function of proteins by modulating their subcellular localization.
Protein Signaling Domains Laboratory
Dr. Daniel G. S. Capelluto
Biological Sciences Department
Biocomplexity Institute Room 263C
1015 Life Science Circle
Blacksburg, VA 24061-0477